Margaret Robinson: Vesicles wear fancy coats

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Margaret Robinson: Vesicles wear fancy coats

T he vesicular coat protein clathrin was discovered in 1975. Since then, remarkable progress has been made in understanding vesicular biology. Yet researchers today are still working to understand how clathrin and other vesicular coat proteins give vesicles their characteristic structure and manage vesic-ular cargoes. Margaret " Scottie " Robinson fi rst heard about clathrin-coated vesicles soo...

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Should doctors wear white coats?

OBJECTIVE To compare the views of doctors and patients on whether doctors should wear white coats and to determine what shapes their views. METHODS A questionnaire study of 400 patients and 86 doctors was performed. RESULTS All 86 of the doctors' questionnaires were included in the analysis but only 276 of the patients were able to complete a questionnaire. Significantly more patients (56%)...

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Transport vesicles: Coats of many colours

Clathrin-coated vesicles transport proteins and membranes between intracellular compartments. Adaptor molecules determine vesicle specificity; recently, a third type of adaptor protein, AP3, has been identified and implicated in the biogenesis of endosomal and lysosome-related organelles.

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Tailoring Uniform Coats for Synaptic Vesicles during Endocytosis

Intermingling of SVs and the plasma membrane during exocytosis poses a serious challenge to the clathrin-dependent endocytic machinery because the composition of vesicular lipids and proteins is different from that of the plasma membrane. This prompts the question of how clathrin and its adaptor proteins correctly distin-† Laboratory of Genetics guish the vesicular components and efficiently re...

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fancy ∗

1 The s-wave repulsion and deeply bound pionic atoms: fact and fancy * Fits to a large data set of pionic atoms show that the 'missing' s-wave repulsion is accounted for when a density dependence suggested recently by Weise is included in the isovector term of the s-wave pion optical potential. The importance of using large data sets is demonstrated and the role of deeply bound pionic atom stat...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2014

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb.2066pi